Metabolic Health

Muscle Loss & Drugs Like Ozempic – What is the Evidence?

Metabolic Health, Weight Loss / By

The advent of GLP-1 receptor agonists, such as semaglutide (marketed as Ozempic and Wegovy), has brought promising prospects for weight loss and overall metabolic health improvement (Kim & Kim, 2020). These medications have demonstrated their effectiveness in shedding unwanted pounds and potentially enhancing cardiovascular and metabolic well-being. However, this scientific inquiry delves into a pertinent concern: does the pursuit of weight loss through these pharmacological interventions come at the expense of one’s invaluable muscle mass (Srikanthan & Karlamangla, 2014)? This article will examine the current body of evidence on the impact of GLP-1 receptor agonists on muscle mass and strength, shedding light on whether these benefits indeed come with a price (Ashtary-Larky et al., 2020).

Read more…

How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience

Metabolic Health, Neuroscience, Weight Loss / By

How do drugs like Ozempic (semaglutide) cause weight loss? What happens when someone comes off of these drugs? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects.

Is it Possible to be Healthy and Obese?

Metabolic Health / By

Is it possible to be metabolically healthy and overweight or obese? In this episode, we discuss the science of what makes fat healthy or unhealthy. We discuss how metabolic dysfunction in fat tissue can affect the rest of the body. We also review evidence pertaining to the “obesity paradox” and explore explanations for the associations of body mass index (BMI) and changes in the risk of disease complications and mortality. We discuss how metrics of central obesity can be used to obtain a better picture of an individual’s metabolic health. Lastly, we discuss the critical link between exercise capacity and future health, as well as how to begin to transform our existing fat stores into a healthier state.

How Super-Athletes Use FAT for Fuel

Metabolic Health / By

In this episode, we discuss fat through the lens of performance and survival, and what happens when we push our energy systems to their limits. We also talk about how our bodies make adaptations via exercise to improve our ability to “burn” fat for fuel, and how our bodies conserve fuel during times of negative energy balance. Lastly, we preview the role of fat as an endocrine organ and the importance of its communication with the brain, as well as the critical role of exercise capacity for our future health.